Secondly, the term of patent protection ...

Secondly, the term of patent protection for many drug-sales leaders will expire, and in the next two-three-year market share of manufacturing companies, will decrease as a result of the market of generic drugs. Obviously, the optimal solution in this situation is the concentration of resources in research and the union offered to the market product range. In addition, each year increasing costs of conducting research in the field of pharmacy. In recent years, pharmaceutical companies spending on research and development increased significantly. For example, if in 1976 such costs for one new drug at an average of $ 125 million, in the mid-90's - about 300-500 million dollars. As a result of mergers of pharmaceutical companies top 10 pharmaceutical companies of the world took up almost half of the world pharmaceutical market (according to preliminary results, 45.5% in sales volume combined companies as at October 1999), while in 1996 this figure was 34 8%. Thus, the process of concentration of the world pharmaceutical market is growing rapidly. As for Russia, the overall production of the ten world's largest companies (according to their merger) covers about 12% of Russian market. Efficiency and quality of drug services for the population is largely determined by the full range of medicines in pharmacies and optimize the management of medical stocks, avoiding, on the one hand, the deficit, on the other - the excess of established standards of commodity stocks. Demand for drugs is a form of expression needs (whether actual, realized and unfulfilled) and can be identified by sociological methods [10]. Analysis of laws affecting the consumption of drugs can improve the system to meet the needs of the population and health facilities in the medicines. Their consumption depends on the emergence of new treatments and drugs, the presence of analogues. Much of the nomenclature of the global medicines market (70%) are in preparations counterparts. At the same time taking into account the varying quality of drugs, analogues and anti-monopoly positions is desirable to have a fairly large selection of drugs [4]. Dynamics of drug consumption is seasonal and from year to year varies considerably [5]. N. Luknarova et al [3] showed that the consumption of drugs increases with age and is higher in women than in men. The most commonly used drugs of the following groups: analgesics, antipyretics, antibiotics, vasodilators, antirheumatic, antipsychotics. BL Parnovskii and others [6] as a result of sociological studies have revealed that the demand for drugs is dependent on gender, age and social structure of the population. More than 81% of the demand for cardiovascular drugs have on the population over age 40, age of strong demand for women is 55-59 years for men - over 60 years.